Микроботы спешат на помощь

Presents robotic white blood cells for targeted drug delivery


A month ago, from boredom or ignorance, there was a wave of fear of nanodevices implanted in the human body. Meanwhile, controlled or automatically moving in the human body nanobots could help with the delivery of drugs to the site of the disease. For example, this is relevant for the treatment of cancer, when drugs successfully kill not only cancer cells, but also the patient’s body. Over time, this will become possible, and it will save lives.

Microbots rush to the rescue

Microbots rush to the rescue

Researchers at the Max Planck Institute have proposed robotic white blood cells that can move and deliver medicine through blood vessels even against blood flow. The developers claim that they created the first such solutions. Small robotic spheres with a diameter of less than 8 microns can move in blood vessels in any direction at a speed of up to 600 microns / s, which corresponds to the movement of each of them in one second by 76 diameters.

An external rotating electromagnetic field is responsible for the movement of the spheres through the blood vessels. The direction of rotation of the field controls the direction of rotation of the microspheres in the human body. Changing it, scientists set the direction of motion for the microspheres. The process of moving microspheres is based on the laws of hydrodynamics. The difference between the blood flows in the middle of the vessels and near the walls allows the rotating microspheres to translate up or down the vessels.

The microsphere itself is made of silicon oxide. In fact, made of glass. To interact with the electromagnetic field, one half of the sphere is coated with gold and nickel. Is the second half of the sphere coated with an antibody specific for a particular disease? and contains the medicine in a bound form. When microspheres reach the site of the disease, antibodies in their half automatically adhere to diseased cells and hold the microsphere in place. Scientists can only send a signal to enter the medicine, which can be done using ultraviolet radiation. Irradiating the sore spot and the accumulation of “anchored” microspheres with ultraviolet light destroys the drug-binding substance, and it is delivered to the treatment site.

Microsphere images and principle of action (Science Robotics)

Microsphere images and principle of action (Science Robotics)

The research team sees a lot of work ahead of itself to bring the invention to practical implementation. But scientists hope that their methodology will eventually allow to treat a number of serious diseases without surgical intervention. We add the article on the work done can be found at this link in the journal Science Robotics.

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